B2M-/Etrimer Elf1
** This cell line has an unexpected abnormal karyotype. Please see the karyotype report in the ``Product Information & Testing`` PDF(s) linked below for more information.
This Beta2Microglobulin-targeted cell line is a modified version of Elf1. One allele is negative for B2M, the other expresses an HLA-E single-chain trimer which contains an additional (G4S)3 linker fused to a peptide derived from the signal sequence of HLA-G, a non-polymorphic peptide normally presented by HLA-E that inhibits NK cell-dependent lysis through its binding to CD94/NGK2A.
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Cell Line Alias
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-/Etrimer |
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Cell Type
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Modified Human ES |
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Disease
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None reported |
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Genetic Alteration/Mutation
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B2M |
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Genetic Modification Keyword
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Isogenic; Immune rejection |
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Sex
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Female |
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Genetically Related Cell Lines
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Provider
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University of Washington - Dr. David Russell |
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dbGaP Data
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hPSCReg ID
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NIH Approval
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Pub Med Abstract
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Related Products
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